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Dermatology Services: Vitiligo and Skin Pigment Disorders

UC Irvine Health provides specialized treatment for patients with vitiligo and other disorders affecting the skin's pigment.

Vitiligo (vit-ill-EYE-go) is a disorder that causes patches of skin to lose their normal pigment. This condition can appear anywhere there are pigmented cells on the body, including hair and tissues inside the nose, mouth and eyes. 

It is not contagious nor is it life-threatening. However, unpigmented skin is very sensitive to sunburn and patients also experience increased itching in affected areas.

A greater concern is that many vitiligo patients suffer from depression over their appearance and the social stigma they experience. This is a significant health problem that needs to be treated.

We also treat hyperpigmentation disorders, which occurs when the skin produces too much pigment in response to a stimulus. These conditions can include melasma, lentigines and post-inflammatory hyperpigmentation.

Our vitiligo and hyperpigmentation disorders service is led by Dr. Anand Ganesan, a board-certified dermatologist who specializes in skin pigment disorders. To make an appointment at the Dermatology Center in Irvine, call 949-824-0606.

What causes vitiligo?

The cause of vitiligo isn’t known, but there may be a genetic component to the disorder. We know that patients with vitiligo have more sensitive pigment cells (melanocytes). Damage to these cells — from trauma, sunburn or other causes — can trigger an autoimmune reaction that destroys the melanocytes and turns the skin white. 

Signs and symptoms of vitiligo 

There are no symptoms other than the loss of color in the affected areas. These patches of skin are chalk white in color because they have no pigment. Patches typically appear on:

  • The face, usually around the mouth, eyes and nose
  • Hands and arms
  • Feet and legs

Treatments for vitiligo

At UC Irvine Health, we work with each patient to develop a treatment plan to achieve maximum results. Our approaches include:

Topical and oral therapies to prevent progression — The first step in treating vitiligo is to prevent the condition from getting worse. To do this we use a combination of topical and oral therapies for the affected areas, including B complex vitamins and antioxidants.

While these therapies provide only minimal improvement in established vitiligo areas, they may prevent further spread of the disease.

Light therapy for vitiligo — We use both narrow band ultraviolet A and B treatments, as well as home light therapy modalities to treat the disease. The approach for treating vitiligo is different from those used to treat psoriasis or other skin disorders, and treatment protocols must be tailored to each patient to achieve optimal results.

Our light therapy nurses have many years of experience in treating the disease, and there is always a physician on hand to assist with questions as they arise during the course of light therapy.

We monitor each patient throughout the course of treatment using a team approach that involves nurses and physicians.

Laser therapy — We use an  excimer laser to treat vitiligo at higher doses. All light therapy works by activating melanocyte stem cells, which are localized around the hair follicles, and stimulating these cells to migrate out of the hair and into the skin.

Excimer laser therapy works better for some patients than standard light box therapy because the treatment can be targeted to a specific area and at higher doses. This method, which we have developed and used for many years, is also tailored to the needs of each patient.

UC Irvine Health vitiligo patient before excimer laser treatment

Before laser treatment


UC Irvine Health vitiligo patient after excimer laser treatment

After laser treatment

Skin grafting — We may perform skin grafts on specific areas that show resistance to other therapies. This involves taking small pieces of normally pigmented skin and placing them in areas with vitiligo.

Each grafted area is then treated with light therapy to stimulate melanocyte stem cells to migrate into the surrounding unpigmented skin. These grafts are very tiny (one millimeter in size) so there is minimal scarring noticeable after the procedure.

UC Irvine Health vitiligo patient before skin graft therapy

Before skin graft


UC Irvine Health vitiligo patient after skin graft therapy

After skin graft

Additional help for vitiligo patients

On Sept, 27, 2015, we are sponsoring a symposium titled “Advances in Vitiligo Research and Care.” This patient-centered event will offer presentations on the latest research and treatments for vitiligo as well as a chance to meet people living with the condition from around the world.  Learn more about the symposium ›

What are hyperpigmentation disorders?

Unfortunately, many dermatologists don’t appreciate the complexity of hyperpigmentation disorders, and often classify every disease as melasma, which causes dark patches to appear on the face. At the UC Irvine Health, we make every effort to assess each patient's condition. This involves careful examination and analysis to determine the location of melanocytes in the affected skin areas, and additional studies to find a possible cause.

Treatments for hyperpigmentation disorders

Treatment of hyperpigmentation disorders is complex and depends on correctly diagnosing the cause. Treatments may involve skin lightening agents and, depending on the cause, possibly immunosuppressive medications. Laser therapy may also be indicated.

We develop a specific treatment plan for each patient, and that may involve multiple therapies.

Make an Appointment

949-824-0606