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Comprehensive Brain Tumor Program: Research

Our UC Irvine Health brain tumor specialists are actively researching new therapies for patients with brain, spine and peripheral nerve tumors.

As physicians with the Chao Family Comprehensive Cancer Center, Orange County's only National Cancer Institute-designated comprehensive cancer center, our Brain Tumor Program specialists are involved in basic research as well as clinical trials, providing our patients with access to leading-edge treatments and therapies generally not available elsewhere.

Open trials

We are enrolling patients in these clinical trials:

  • A phase II clinical trial evaluating DCVax®-Brain, autologous dendritic cells pulsed with tumor lysate antigen for the treatment of glioblastoma multiforme (UCI-08-16)
  • Phase III study of radiation therapy with or without temozolomide for symptomatic or progressive low-grade gliomas (ECOG-E3F05)
  • An international, randomized, double-blind controlled study of rindopepimut/GM-CSF with adjuvant temozolomide in patients with newly diagnosed, surgically resected, EGFRvIII-positive glioblastoma (UCI-11-46)
  • A phase II study of rindopepimut/GM-CSF/GM-CSF in patients with relapsed EGFRvIII-positive glioblastoma (UCI-12-01)

Learn more about these and our other clinical trials for cancers of the brain and nervous system ›

Basic science research

Our brain tumor specialists also conduct translational tumor research, as well as studies of the basic molecular biology of brain tumors.

Research studies by Dr. Daniela Bota and Dr. Jose Carrillo seek to translate basic scientific advances into therapeutic treatments at the cancer center. They also work with researchers at the UC Irvine Health Beckman Laser Institute & Medical Clinic on the use of modulated imaging to investigate brain tumors and intraoperative mapping.

Other studies involve pathways to suppress tumor growth and development. In addition, we are exploring the differential biology of tumor stem cells versus the main tumor cell population, and the molecular modeling of brain tumor patient prognosis.

For more information or to make an appointment, please call 714-456-8000 or email us.  A team physician will respond within 24 hours.

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