Dr. William Karnes, UC Irvine Health gastroenterologist and colon cancer screening specialist

William E. Karnes
, MD

Gastroenterology (Digestive System)
Colon Cancer Screening

UC Irvine Health H.H. Chao Comprehensive Digestive Disease Center
101 The City Drive South, Building 23, 3rd floor
Orange, CA 92868
Phone: 888-717-GIMD (888-717-4463)
UC Irvine Health Digestive Disease Center — Newport
Pacific Medical Plaza
1640 Newport Blvd., Suite 350
Costa Mesa, CA 92627
Phone: 888-717-4463
UC Irvine Health Gottschalk Medical Plaza
1 Medical Plaza Drive
Irvine, CA 92697
Phone: 949-824-8600
  • American Board of Internal Medicine — Gastroenterology
  • American Board of Internal Medicine — Internal Medicine
Clinical Interests
  • Colon cancer screening
  • Colorectal neoplasia, early detection and prevention
  • High-risk families for colorectal cancer
  • Gastrointestinal bleeding
  • General gastroenterology and hepatology
  • Gastroesophageal reflux disease (GERD)
  • Capsule endoscopy
  • Celiac disease
  • Development of colorectal neoplasia clinic registry
  • Esophageal disease
  • Esophageal cancer
  • Irritable bowel syndrome
  • Translational research emphasizing screen and prevention of colorectal cancer
  • English
Medical School
University Minnesota Medical School, Minneapolis, Minn.
University Minnesota Medical School — Chief Resident, Internal Medicine
University Minnesota Medical School — Internal Medicine
Mayo Clinic, Rochester, Minn. — Molecular Biology
UCLA Medical Center — Gastroenterology
Professional Positions
  • Associate Professor — Division of Gastroenterology & Hepatology, Department of Medicine
  • Fellow — American Gastroenterological Association
  • Member — American Association for Cancer Research
  • Member — American Association for the Advancement of Science
  • Member — American College of Physicians
  • Member — American Medical Association
  • Member — California Medical Association
Awards and Recognition
  • Best Doctors in America® — Gastroenterology, 2015, 2016
  • American Federation of Clinical Research Award, 1995
  • Merck Fellowship Training Grant, 1987-88
  • National Institutes of Health Fellowship Training grants, 1987-88 and 1990-92
  • Young Scholar Award, World Congress of Gastroenterology, 1994
More Information

Dr. William Karnes is a UC Irvine Health gastroenterologist who specializes in disorders of the gastrointestinal tract, including colorectal cancer screening, gastrointestinal reflux disease (GERD), swallowing disorders, irritable bowel syndrome, peptic ulcers and esophageal disorders. He performs colonoscopies, upper endoscopies and capsule endoscopies, and treats gastrointestinal bleeding, chronic diarrhea, constipation, bloating and bacterial problems in the small intestines.

He also conducts translational research on colon cancer prevention, with an emphasis on regular colorectal screening, especially among patients and families with a genetic risk for developing the disease.

Karnes earned his medical degree from the University of Minnesota Medical School in Minneapolis, where he completed a residency in internal medicine. He went on to complete a fellowship in molecular biology at Mayo Clinic in Rochester, Minn., and a fellowship in gastroenterology at the University of California, Los Angeles.

Speakers Bureau Topics

  • Celiac Disease
  • Chronic Diarrhea
  • Colon Cancer Screening, Diagnosis and Treatments
  • Colon Cancer: Genetic Risk Factors
  • Eosinophilic Esophagitis
  • Gastroesophageal Reflux Disease (GERD)
  • H. Pylori and Peptic Ulcer Disease
  • Small Intestinal Bacterial Overgrowth (SIBO)