William E Karnes

William E. Karnes
, MD

Gastroenterology (Digestive System)
Colon Cancer Screening

Office Locations

UC Irvine Health H.H. Chao Comprehensive Digestive Disease Center
101 The City Drive South, Building 22C
Orange, CA 92868
Phone: 888-717-GIMD (888-717-4463)
UC Irvine Health Gottschalk Medical Plaza
1 Medical Plaza Drive
Irvine, CA 92697
Phone: 949-824-8600
  • American Board of Internal Medicine — Gastroenterology
  • American Board of Internal Medicine — Internal Medicine
Clinical Interests
  • Colon cancer screening
  • Colorectal neoplasia, early detection and prevention
  • High-risk families for colorectal cancer
  • Gastrointestinal bleeding
  • General gastroenterology and hepatology
  • Gastroesophageal reflux disease (GERD)
  • Capsule endoscopy
  • Celiac disease
  • Development of colorectal neoplasia clinic registry
  • Esophageal disease
  • Esophageal cancer
  • Irritable bowel syndrome
  • Translational research emphasizing screen and prevention of colorectal cancer
  • English
Medical School
University Minnesota, Minneapolis
University Minnesota, Minneapolis, Chief Resident, Internal Medicine
University Minnesota, Minneapolis, Internal Medicine
Mayo Clinic, Rochester, MN, Molecular Biology
UCLA, Gastroenterology
Professional Positions
  • Associate Clinical Professor — Division of Gastroenterology, Department of Medicine
  • Fellow — American Gastroenterological Association
  • Member — American Association for Cancer Research
  • Member — American Association for the Advancement of Science
  • Member — American College of Physicians
  • Member — American Medical Association
  • Member — California Medical Association
Awards and Recognition
  • American Federation of Clinical Research Award, 1995
  • Merck Fellowship Training Grant, 1987-88
  • National Institutes of Health Fellowship Training grants, 1987-88 and 1990-92
  • Young Scholar Award, World Congress of Gastroenterology, 1994
More Information

Dr. Karnes is a fellowship-trained gastroenterologist who specializes in disorders of the gastrointestinal tract, including colorectal cancer screening, gastrointestinal reflux disease (GERD), swallowing disorders, irritable bowel syndrome, peptic ulcers and esophageal disorders. He performs colonoscopies, upper endoscopies and capsule endoscopies, and treats gastrointestinal bleeding, chronic diarrhea, constipation, bloating and bacterial problems in the small intestines. He also conducts translational research on colon cancer prevention, with an emphasis on regular screening, especially among patients and families with a genetic risk for developing the disease.

Academic Profile

View this doctor's academic profile ›

Speakers Bureau Topics

  • Celiac Disease
  • Chronic Diarrhea
  • Colon Cancer Screening, Diagnosis and Treatments
  • Colon Cancer: Genetic Risk Factors
  • Eosinophilic Esophagitis
  • Gastroesophageal Reflux Disease (GERD)
  • H. Pylori and Peptic Ulcer Disease
  • Small Intestinal Bacterial Overgrowth (SIBO)