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A Phase 2, Proof-of-Concept, Double-Blind-Randomized, Placebo-Controlled Adaptive Design Trial of Nicotinamide in MCI Due to AD and Mild AD Dementia

This research study seeks participants to evaluate if nicotinamide can reduce phosphorylation in subjects with mild cognitive impairment or mild...
Joshua Grill, PhD, and Aimee Pierce, MD

UCI campus (1100 Gottschalk Medical Plaza, Irvine; ICTS at Hewitt Hall, Irvine and Newport Diagnostic Center, Newport Beach); UCLA Center for Neurotherapeutics (UCLA Medical Center, 300 Medical Plaza, Westwood Blvd., Los Angeles).

A Phase 2b/3 Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter Study Investigating the Efficacy and Safety of JNJ-54861911 in Subjects Who Are Asymptomatic at Risk for Developing Alzheimer's Dementia

This research study seeks participants to study the efficacy and safety of JNJ-54861911 in those who are asymptomatic at risk for developing...
Aimee L. Pierce, MD

UCI campus (UCI MIND Gottschalk Medical Plaza, ICTS in Hewitt Hall Neuroscience Imaging Center in Irvine Hall) in Irvine

A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Aducanumab (BIIB037) in Subjects with Early Alzheimer's Disease

This research study seeks participants to study the efficacy and safety of aducanumab in subjects with early Alzheimer's disease.
Aimee Pierce, MD

UCI campus (UCI MIND Gottschalk Medical Plaza, ICTS in Hewitt Hall, Neuro Imaging Center), Newport Diagnostic Center

Alzheimer's disease neuroimaging initiative 2 (ADNI2)

Steven G. Potkin, MD

UC Irvine Medical Center and the UC Irvine Brain Imaging Center for the PET scan portion of the study

Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4 Study)

Aimee L. Pierce, MD

UCI MIND at Gottschalk Medical Plaza, UC Irvine Health Institute for Clinical & Translational Science at Hewitt Hall on the Irvine campus, the UC Irvine Brain Imaging Center in Irvine Hall.

The Piromelatine Study for adults with memory problems

UC Irvine Medical Center is seeking adults with memory loss issues for a research study to determine the effectiveness of an investigational drug.
Steven Potkin, MD

UC Irvine Medical Center in Orange