Magnetic resonance imaging in psychiatric patients and controls

Schizophrenia, Psychiatry
Theo Van Erp, PhD

UC Irvine Medical Center and UC Irvine

The purpose of this research study is to learn how memory is carried out in the human brains of patients with and without schizophrenia. This research study is designed to help further our understanding of what structures might operate differently when compared with people without schizophrenia. Understanding what structures are involved and how they interoperate will not only lead to a better understanding of the human brain as a whole, but also may lead to potential strategies for assisting schizophrenia patients with memory impairments.
Adults what are between 18 and 65 years of age, inclusive, and have no contraindications to MRI scanning.
This study includes 4 visits (about 5 hours) for healthy subjects and 5 visits (about 7.5 hours) for patients with schizophrenia over a period of up to one month. Some subjects will be asked to come back to repeat the visits for a longitudinal follow-up, with participation in 10 visits and roughly 15 hours over a period of ten weeks. Some visits may be done on the same day, depending on subject availability.
Subjects will receive $20 per hour for the initial screening and completion of the clinical ratings interview with a physician regardless of
whether the subject qualifies for the subsequent test in the scanner, $20 per hour for additional ratings interviews including the neurocognitive computer tasks. Partial hours will be paid as full hours (e.g. if your clinical interview lasts 1 hour and 20 minutes, you will receive $40). Subjects will receive $25 after the completion of each MRI scanning visit lasting between one and two hours. If you are asked to repeat the scan due to equipment failure and/or excessive movement, you will receive an additional $25 or $50 depending on the length of the visit. Subjects will receive cash compensation at the end of each visit.Compensation: Total payment for participation in this study is up to $450.
Andrea Weiderman