Low-residue diet versus clear liquid diet with split dose PEG-ELS for colon cleansing prior to colonoscopy, a randomized trial

HS 2014-1306
Digestive Disease
Jason Samarasena, MD

UC Irvine Health H.H. Chao Comprehensive Digestive Disease Center

This is a randomized, single-blind, controlled, parallel-group prospective trial to compare the efficacy of bowel cleansing and tolerability of split-dose PEG-ELS (Golytely) when taken following a clear liquid diet versus low-residue diet prior to a scheduled colonoscopy.

Any patient ages 18 to 80 who will be scheduled for screening or diagnostic colonoscopy.

Any additional time spent on research-related activity would be the time encountered during the preparation for and performance of a typical colonoscopy.
If a low-residue diet prior to bowel preparation is found to be safe, effective and tolerable compared with the current standard of clear liquid diet, then bowel preparation prior to colonoscopy may become a more comfortable experience for a large number of patients in the future. Improved patient tolerance may lead to increased rates of colorectal cancer screening among patients who fear the bowel preparation and dietary restrictions associated with colonoscopy.


Jason Samarasena, MD