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Treatment powered by poop may cure deadly diarrhea

April 01, 2015 | Patricia Harriman
ParekhNimisha261

Dr. Nimisha Parekh, director of the UC Irvine Health inflammatory bowel disease program

Poop is on the cutting-edge of research into the cure for Clostridium difficile, a diarrhea that is one of the most deadly, hard-to-eradicate and common infections.

According the latest CDC data published recently in The New England Journal of Medicine, C. diff caused 500,000 illness and 29,000 deaths in 2011, higher than any previous year.

Physicians with UC Irvine Health are using a promising experimental treatment called fecal microbiota transplant, or FMT, which involves placing the stool of a healthy donor into a sick person’s intestine. Research has found that gut microbiomes are essential to digestive health, and the microbiomes in healthy donor stool may help to restore proper bacterial balance and eliminate the C. diff infection.

Dr. Nimisha Parekh, director of the UC Irvine Health inflammatory bowel disease program, is investigating FMT’s effectiveness as an experimental treatment for treating C. diff infections that don’t respond to drugs.

Patients like 58-year-old Michael Moeller, who had been suffering from increasingly debilitating diarrhea for more almost a year, despite taking antibiotics.

“I felt physically better in just one day,” Moeller said.

Patient response is evaluated at four and eight weeks after treatment by testing stool samples for signs of the infection.

Gut bacteria — a complex world

“There are more than 1,000 species of microorganisms in the human gut, and we are only beginning to understand the complex functions that our gut bacteria perform,” Parekh said.

“The results of this study will add to our understanding of how the bacterial composition of a healthy donor’s stool helps fight the C. diff infection. Our ultimate goal is to identify and isolate the specific bacteria that will beat this bug.”

C. diff treatment challenges

C. diff releases toxins that attack the lining of the intestine, resulting in fever, cramps and severe diarrhea.

Antibiotics, which usually save lives, can actually put patients at risk by killing off the naturally occurring intestinal bacteria that normally keep C. diff in check, and are often ineffective for treatment. The chance for recurrence is 20 percent after initial treatment with standard drugs, and jumps up to 40 percent to 65 percent after the second episode.

This high failure rate has prompted the quest for more effective treatments, and stimulated a renewed interest in FMT, which has deep roots in veterinary science. Fecal enemas were first used in 1958 to treat pseudomembranous colitis, and administered in 1983 for C. diff infections.

UC Irvine has been authorized by the Food and Drug Administration to administer the FMT treatment, currently classified as an investigational drug. 

Comments

Charley Miller, RN - ARU
May 02, 2015

I am interested in presenting an inservice to my Acute Rehabilitation Unit on FMT. I would appreciate any information you could provide to assist in my inservice to educate our staff and to whom we could encourage our MD's to consult for our patients that show poor response to conventional antibiotic treatment.

Thank you for your consideration of this request.

Charley Miller

Yuna Muyshondt, MPH - Clinical Research Administrator
May 15, 2015

Charley, I would be happy to share information about FMT. Please contact me at (714) 456-2215 or email me at chuny@uci.edu

Ginger Sullivan
June 16, 2015

I have been suffering with IBS and an undiagnosed autoimmune disease for many years now. I have been in bad condition. I believe that I would really benefit from FMT. My spirit is shot because nothing I do really helps and I am exhausted. Will FMT become available for those suffering from IBS, SIBO and an autoimmune disease, like me?

Dr. Nimisha Parekh
July 07, 2015

Thank you very much for your post, Ginger. At this time, FMT is under investigation for various different conditions and we hope to have a lot of new information in the next few years.

Eric Tang
August 27, 2015

Out of curiosity, are you still looking for people to donate?

Amy
October 06, 2015

Hi, Would FMT be used for chronic BV patient as well? Thank you

Natalie Lily
November 10, 2015

I have had diarrhia for over a year,and have not really find cure, i have try all medication is not working out for me but it was the only the herbel of dr.abegbu i took that cure me totally i am free now from diarrhia if you need his help you can reach him through his email dr.abegbuhealer@gmail.com

Nancy Negrete
September 10, 2016

Please help me, I'm not getting better and desperate.

My son was born 5/9/16, placenta was retained in my csection, 7/11/16 D&C, 8/1/16 hysterectomy. After a month suffering 8/30/16 I was diagnosed with Cdiff.

UC Irvine Health
September 11, 2016

Hi Nancy. Please contact our Inflammatory Bowel Disease Program for help with C. diff infections. You can contact the program at 888-717-4463 or by filling out an appointment request form. We hope you find relief soon.

Raquel Baltierra
April 28, 2017

I left a message last week. I am a patient with a second round of Cliff in two weeks. I would like to know what I could do to find out about getting help on a fecal transplant.

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